Rabies virus immune evasion

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Infectious disorders drug targets. View 3 excerpts, references background. Paramyxovirus evasion of innate immunity: Diverse strategies for common targets. World journal of virology. Rabies virus phosphoprotein P protein is a multifunctional protein that plays key roles in replication as the polymerase cofactor that binds to the complex of viral genomic RNA and the nucleoprotein N protein , and in evading the innate immune response by binding to STAT transcription factors.

The colocation of these binding sites in the small globular PCTD raises the question of how these interactions underlying replication and immune evasion, central to viral infection, are coordinated and, potentially, coregulated. While direct data on the binding interface of the PCTD for STAT1 is available, the lack of direct structural data on the sites that bind N protein limits our understanding of this interaction hub.

The PCTD was proposed to bind via two sites to a flexible loop of N protein Npep that is not visible in crystal structures, but no direct analysis of this interaction has been reported.

Furthermore, in contrast to previous predictions we identify a single site of interaction on the PCTD by this Npep.